血红素
催化作用
共价键
卟啉
化学
纳米孔
活动站点
组合化学
活动中心
酶
纳米技术
有机化学
材料科学
作者
Xi-Sen Wang,Matthew Chrzanowski,Daqiang Yuan,Brandon S. Sweeting,Shengqian Ma
摘要
Although the active centers of many metalloenzymes have been well-studied, the ability for chemists to imitate the iron porphyrin heme found in these enzymes remains a challenge. Herein, we report a water/chemical-stable nanoporous covalent heme framework (CHF-1) that can be synthesized via the Yamamoto homocoupling reaction. Unlike other artificial enzymes, CHF-1 neatly arranges the heme centers to form a graphene-like two-dimensional framework bearing a high surface area (1620 m2/g) and high density of active sites. Biomimetic catalytic reactions show that CHF-1 catalyst is an effective heterogeneous catalyst with exceptionally high binding affinities and high catalytic efficiency approaching that of natural heme-based enzymes.
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