腹主动脉瘤
弹性蛋白
医学
主动脉瘤
变硬
主动脉
动脉瘤
心脏病学
内科学
病理
外科
材料科学
复合材料
作者
Uwe Raaz,Alexander M. Zöllner,Isabel N. Schellinger,Ryuji Toh,Futoshi Nakagami,Moritz Brandt,Fabian Emrich,Yosuke Kayama,Suzanne M Eken,Matti Adam,Lars Mäegdefessel,Thomas Hertel,Alicia Deng,Ann Jagger,Michael Buerke,Ronald L. Dalman,Joshua M. Spin,Ellen Kuhl,Philip S. Tsao
出处
期刊:Circulation
[Ovid Technologies (Wolters Kluwer)]
日期:2015-05-19
卷期号:131 (20): 1783-1795
被引量:113
标识
DOI:10.1161/circulationaha.114.012377
摘要
Background— Stiffening of the aortic wall is a phenomenon consistently observed in age and in abdominal aortic aneurysm (AAA). However, its role in AAA pathophysiology is largely undefined. Methods and Results— Using an established murine elastase-induced AAA model, we demonstrate that segmental aortic stiffening precedes aneurysm growth. Finite-element analysis reveals that early stiffening of the aneurysm-prone aortic segment leads to axial (longitudinal) wall stress generated by cyclic (systolic) tethering of adjacent, more compliant wall segments. Interventional stiffening of AAA-adjacent aortic segments (via external application of surgical adhesive) significantly reduces aneurysm growth. These changes correlate with the reduced segmental stiffness of the AAA-prone aorta (attributable to equalized stiffness in adjacent segments), reduced axial wall stress, decreased production of reactive oxygen species, attenuated elastin breakdown, and decreased expression of inflammatory cytokines and macrophage infiltration, and attenuated apoptosis within the aortic wall, as well. Cyclic pressurization of segmentally stiffened aortic segments ex vivo increases the expression of genes related to inflammation and extracellular matrix remodeling. Finally, human ultrasound studies reveal that aging, a significant AAA risk factor, is accompanied by segmental infrarenal aortic stiffening. Conclusions— The present study introduces the novel concept of segmental aortic stiffening as an early pathomechanism generating aortic wall stress and triggering aneurysmal growth, thereby delineating potential underlying molecular mechanisms and therapeutic targets. In addition, monitoring segmental aortic stiffening may aid the identification of patients at risk for AAA.
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