细胞生物学
内体
发病机制
生物
β淀粉样蛋白
转运蛋白
细胞质
阿尔茨海默病
淀粉样蛋白(真菌学)
细胞内
淀粉样前体蛋白
疾病
病理
医学
免疫学
植物
作者
Lydia Herrmann,Caspar Wiegmann,Annika Arsalan-Werner,Isabel Hilbrich,Carsten Jäger,Katharina Flach,Anne Suttkus,Ingolf Lachmann,Thomas Arendt,Max Holzer
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2015-03-23
卷期号:10 (3): e0119423-e0119423
被引量:21
标识
DOI:10.1371/journal.pone.0119423
摘要
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes. Furthermore, Hook proteins are associated with pathological hallmarks in AD; Hook1 and Hook3 are localized to tau aggregates and Hook2 to glial components within amyloid plaques. Additionally, the expression of Hook3 is reduced in AD. Modelling of Hook3 deficiency in cultured cells leads to slowing of endosomal transport and increases β-amyloid production. We propose that Hook3 plays a role in pathogenic events exacerbating AD.
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