激光器
氙气
细胞凋亡
紫外线
材料科学
光电子学
光学
化学
生物化学
物理
有机化学
作者
Zoltán Novàk,Béla Bónis,Eszter Baltás,Imre Ocsovszki,Ferenc Ignácz,A. Dobozy,Lajos Kemény
标识
DOI:10.1016/s1011-1344(02)00280-4
摘要
Earlier we reported that a 308-nm xenon chloride (XeCl) UVB laser is highly effective for treating psoriasis. As ultraviolet B light seems to cause T cell apoptosis, in the present study we studied the ability of the XeCl laser to induce T-cell apoptosis in vitro, and then compared the apoptosis-inducing capacities of narrow-band UVB (NB-UVB) light and the XeCl laser. The role of laser impulse frequency and intensity in the therapeutical and apoptosis-inducing efficacy of XeCl laser was also investigated. Both XeCl laser and NB-UVB induced T cell apoptosis, but quantitative induction was greater with XeCl laser. Changes in the frequency and intensity of impulses of XeCl laser did not influence its therapeutic and T cell apoptosis-inducing efficacy. These results suggest that the more effective induction of T cell apoptosis can be responsible for the greater clinical efficacy of XeCl laser compared to NB-UVB. Additionally, the optical properties of the XeCl laser (a monochromatic, coherent, pulse-mode laser; easier precise dosimetry, there are no 'contaminating' wavelengths) can make this laser light an ideal tool for studies of the mode of action of UVB light.
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