化学
生物转化
萘普生
黑曲霉
代谢物
色谱法
质谱法
萃取(化学)
有机化学
生物化学
酶
医学
替代医学
病理
作者
Aimin He,John P. N. Rosazza
出处
期刊:ChemInform
[Wiley]
日期:2003-09-12
卷期号:34 (39)
被引量:5
标识
DOI:10.1002/chin.200339085
摘要
Aspergillus niger ATCC 9142 was used to catalyze the biotransformation of S(-)-naproxen (1) to three major metabolites that were isolated by solvent extraction, purified chromatographically, and characterized by mass spectrometry and NMR spectroscopy. Metabolites were identified as O-desmethylnaproxen (2), 7-hydroxynaproxen (3) and 7-hydroxy-O-desmethyinaproxen (4). The kinetics of naproxen biotransformation to 2 and 4 was established over an 84 h period to show that naproxen was completely metabolized at 36 h, the major metabolite was O-desmethylnaproxen at 24 h, and the 7-hydroxy-O-desmethylnaproxen that was formed after 24 h.
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