生长素
MAPK/ERK通路
细胞外
谷氨酸受体
内分泌学
内科学
分泌物
化学
信号转导
受体
生物
生物化学
医学
作者
Rakhi Chacrabati,Zhi Gong,Chika Ikenoya,Daisuke Kondo,Jeffrey M. Zigman,Takafumi Sakai,Ichiro Sakata
摘要
Ghrelin is abundantly produced in the stomach. Here, we found that glutamate decreased ghrelin expression and release in ghrelin-producing cells, and decreased levels of food intake and plasma acyl-ghrelin in mice. Treatment with siRNA of G protein-coupled receptor, family C, group 5, member B (GPRC5B) in ghrelin-producing cell lines completely blocked the effect of glutamate-induced ghrelin suppression. In addition, glutamate inhibited ghrelin release via the extracellular signal-regulated kinase (ERK) activity pathway, and stimulated CREB2 mRNA expression in ghrelin-producing cell lines. These results suggest that glutamate inhibits ghrelin release via ERK-CREB2 pathway. These results suggest that the GPRC5B-ERK-CREB2 pathway is involved in the inhibition of ghrelin expression and secretion in ghrelin cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI