间充质干细胞
旁分泌信号
再生(生物学)
肌腱
干细胞
细胞生物学
医学
结缔组织
解剖
生物
病理
内科学
受体
作者
Bingyu Zhang,Qing Luo,Alexander Halim,Yang Ju,Yasuyuki Morita,Guanbin Song
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2017-07-30
卷期号:12 (6)
被引量:19
标识
DOI:10.2174/1574888x12666170502102423
摘要
Background: Tendon is composed of connective tissue, is able to retract with high tensile force, and plays a significant role in musculoskeletal motion. However, inappropriate physical training or accidents often result in tendon injuries. So far, the functional healing of injured tendon is still a great challenge in orthopedics. Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, including tenocytes. The plasticity of MSCs gives rise to the chance of improved healing of injured tendons and even tissue-engineered tendons. Recently, more and more works have shown that the paracrine mechanisms of MSCs also play a critical role in driving the tendon repair process. Keywords: Mesenchymal stem cells, directed differentiation, paracrine, tendon, injury, repair.
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