医学
内科学
溃疡性结肠炎
粪便细菌疗法
队列研究
不利影响
队列
随机对照试验
荟萃分析
微生物群
移植
置信区间
临床试验
胃肠病学
肠道菌群
科克伦图书馆
炎症性肠病
出版偏见
结肠炎
粪便
艰难梭菌
失调
免疫学
生物信息学
生物
疾病
抗生素
微生物学
作者
Yan-qiang Shi,Yi-wei Dong,Wenhui Huang,Decong Zhu,Hua Mao,Peizhu Su
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2016-06-13
卷期号:11 (6): e0157259-e0157259
被引量:69
标识
DOI:10.1371/journal.pone.0157259
摘要
Fecal microbiota transplantation (FMT) has been recognized as a novel treatment for ulcerative colitis (UC). However, its efficacy and safety remain unclear.We conducted this systematic review to assess the efficacy and safety of FMT in UC.PubMed, EMBASE, Cochrane Central, Web of Science Core Collection, and three other Chinese databases were searched for reports of FMT in UC with clear outcomes.We estimated pooled rates [with 95% confidence interval (CI)] of clinical remission among 15 cohort studies and clinical response among 16 cohort studies.Twenty five studies (2 randomized controlled trials, 15 cohort studies, and 8 case studies) with 234 UC patients were included. Overall, 41.58% (84/202) patients achieved clinical remission (CR) and 65.28% (126/193) achieved clinical response. Among the cohort studies, the pooled estimate of patients who achieved CR and clinical response were 40.5% (95% CI 24.7%-58.7%), and 66.1% (95% CI 43.7%-83.0%). Most adverse events were slight and self-resolving. The analyses of gut microbiota in 7 studies showed that FMT could increase microbiota diversity and richness, similarity, and certain change of bacterial composition.FMT provides a promising effect for UC with few adverse events. Successful FMT may be associated with an increase in microbiota diversity and richness, similarity, and certain change of bacterial composition.
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