Tumor microenvironment and oral carcinoma-associated fibroblasts

The tumor microenvironment is a system with different characteristics from the normal tissue microenvironment.Carcinoma-associated fibroblasts (CAFs) are the most important cells in tumor microenvironment.Characteristics of the fibroblasts in the oral cancer microenvironment are different from the normal fibroblast cells.The fibroblasts in the oral cancer microenvironment play an important role in cancerogenesis,development,and metastasis.