Hepatic gene transfer of human aquaporin‐1 improves bile salt secretory failure in rats with estrogen‐induced cholestasis

Hepatocyte canalicular expression of hAQP1 through adenoviral gene transfer promotes biliary BS output by modulating BSEP activity in estrogen-induced cholestasis, a novel finding that might help us to better understand and treat cholestatic disorders. (Hepatology 2016;64:535-548).