Changes of levels of Tumor markers in patients with lung cancer before and after chemotherapy and its clinical significance

Objective To discuss the value of lung cancer tumor marker levels change before and after chemotherapy.Methods 228patients with clinically diagnosed patients with lung cancer were analyzed, all passed two cycles of chemotherapy,and observed the tumor markers changes of CEA,NSE and CYFRA21-1before three different types of chemotherapy,and combine with the changes of Chest CT,and evaluate the curative effect.Results The positive rate of CEA,NSE,CYFRA21-1is significantly higher respectively in lung adenocarcinoma,small cell lung cancer(SCLC),squamous carcinoma group than other types of lung cancer(P 0.05).After two weeks′chemotheraphy,CEA was significantly higher with adenocarcinoma than other subtypes of lung cancer(P 0.05);The level of NSE was significantly higher in patients with SCLC than other subtypes of lung cancer(P 0.05);The level of CYFRA21-1was significantly higher in patients with squamous carcinoma than other subtypes of lung cancer(P 0.05);The level of CEA was dropped significantly after chemotherapy in PR patients with adenocarcinoma and increased obviously in PD patients with adenocarcinoma;The level of NSE was dropped significantly before chemotherapy in PR patients with SCLC;The level of CYFRA21-1was dropped significantly before chemotherapy in PR patients with squamous carcinoma.Conclusion The serum determination of CEA,NSE, and CYFRA21-1were conducive to judge the types of tumor cell.The serum change after chemotherapy was closely correlated with the therapeutic effect.