产黄青霉
海绵
真菌
亲缘关系
化学
立体化学
生物
生物化学
植物
作者
Min-Jia Cao,Tao Zhu,Jing‐Tang Liu,Liang Ouyang,Fan Yang,Hou-Wen Lin
标识
DOI:10.1080/14786419.2019.1596099
摘要
Two new sorbicillinoids, 13-hydroxy-dihydrotrichodermolide (1) and 10,11,27,28-tetrahydrotrisorbicillinone C (2), were isolated from the sponge-derived fungus Penicillium chrysogenum 581F1. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 2 displayed high affinities to target proteins GLP-1R (diabetes) and eEF2K (cancer) with Kd values of 0.0285 μM, 0.0162 μM for GLP-1R and 0.118 μM, 0.0746 μM for eEF2K, respectively.
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