卵胞浆内精子注射
微流控
卵母细胞
辅助生殖技术
精子
生物
体外受精
生殖生物学
配子
不育
胚胎
纳米技术
计算生物学
细胞生物学
遗传学
材料科学
怀孕
胚胎发生
作者
Aylin Nikshad,Afsoon Aghlmandi,Reza Safaralizadeh,Leili Aghebati‐Maleki,Majid Ebrahimi Warkiani,Farhad Motavalli Khiavi,Mehdi Yousefi
出处
期刊:Life Sciences
[Elsevier]
日期:2021-01-01
卷期号:265: 118767-118767
被引量:25
标识
DOI:10.1016/j.lfs.2020.118767
摘要
According to World Health Organization (WHO) reports about 70 million couples suffer from infertility all over the world. A lot of research groups are working on this issue and have made therapeutic approaches by integrating biology, medicine, genetics, chemistry, psychology, mechanic, and many other branches of science. However, these methods have their own pros and cons. Assisted Reproductive Technologies (ART) has appeared to solve infertility problems. In Vitro Fertilization (IVF), Intracytoplasmic Sperm Injection (ICSI), Intrauterine Insemination (IUI) are the most common and conventional technologies in this regard. There are at least two characteristics of microfluidics, mechanical and biochemical, which can be influential in the field of mammalian gamete and preimplantation embryo biology. These microfluidic characteristics can assist in basic biological studies on sperm, oocyte and preimplantation embryo structure, function and environment. Using microfluidics in sorting sperm, conducting different steps of oocyte selection and preparation, and transferring embryo by passing sub-microliter fluid through microchannels results in low cost and short time. The size and shape of microchannels and the volume of used fluid differs from non-human cells to human cells. The most progressions have been seen in animal models. Results suggest that microfluidic systems will lead to improved efficiencies in assisted reproduction.
科研通智能强力驱动
Strongly Powered by AbleSci AI