麦角甾醇
喜树酯
豆甾醇
胆固醇
化学
植物甾醇
新陈代谢
生物化学
拉托斯特罗尔
甾醇
脂质代谢
色谱法
作者
Lanlan Yuan,Fan Zhang,Shijie Jia,Mingyong Xie,Mingyue Shen
标识
DOI:10.1016/j.jff.2019.103715
摘要
Phytosterols have been shown to be effective in reducing blood cholesterol by suppressing intestinal cholesterol absorption in both humans and animals. In present study, the inhibition of cholesterol absorption in Caco-2 cells by ergosterol, ergosterol acetate, β-sitosterol, stigmasterol, campesterol and stellasterol were systematically assessed. Results showed that the phytosterols produced cholesterol-lowering effect in Caco-2 cells. This effect was largely mediated via reducing the biosynthesis of cholesterol (HMGCS1); meditating the key proteins in cholesterol transportation and metabolism (NPC1L1, ABCG5/ABCG8); interrupting the conversion of cholesterol to cholesterol esters (ACAT2). Results indicated that their cholesterol-lowering activity may be correlated with the functional group (hydroxyl or ester) on C-3 position (ergosterol < ergosterol acetate) and the functional groups on C-5 position of phytosterols (ergosterol > stellasterol). Further researches are needed to confirm the cholesterol-lowering effects of phytosterols with functional group (methyl or ethyl) on C-24 and the functional groups on C-22 position.
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