Potential relationship between pancreatic histological features and its diseases

Objective To investigate the potential relationship between the pancreatic histological features and its diseases. Methods We collected 49 pancreatic samples from Beijing Hospital and the First Af-filiated Hospital of Xinjiang Medical University from April 2005 to June 2006 to determine the structure of pancreatic peripheral tissue, the structural characteristics of pancreatic lobule and duct in healthy pancreas and its abnormality. Results There were loose connective tissue nccupyiug the frontage and backside of healthy pancreas.The basic unit of pancreas was pancreatic lobule. The blood supply of pancreatic parenchyma was through the gap of pancreatic lobule from periphery. Pancreatic duct was mainly composed of simple epithelial cells and dense connective tissue but not muscular layer.There was dense connective tissue occup-ying the frontage and backside of pancreas while there was chronic pancreatitis happened. The situation presented more apparently with decreasing of distance to lesion of pancreatic tissue. A great deal of fibrous structure and lymphocyte soaked the gap of pancreatic lobule and the gap of pancreatic lobule became wider and pancreatic lobule atrophied. Conclusion Pancreas can not form envelope. Pass structure of the loose connective tissue in the blank of glandular 10bde is in accord with endocrine and exocrine function of pancreas .Difficulty of the therapy in acute pancreatitis, chronic pancreatitis or pancreatic cancer is directly related to the structural features of pancreas. Key words: Pancreatic diseases; Pancreas; Histology; Envelope