坏死性下垂
程序性细胞死亡
化学
溶酶体
癌细胞
流式细胞术
癌症治疗
细胞生物学
人工细胞
内吞循环
纳米技术
细胞
生物物理学
癌症
生物化学
细胞凋亡
生物
酶
材料科学
膜
内吞作用
分子生物学
遗传学
作者
Liangbo Hu,Ying Liu,Xinhui Lin,Yucheng Huo,Hongyue Zhang,Huaimin Wang
标识
DOI:10.1002/anie.202103507
摘要
Abstract Here we report on the design, synthesis, and assembly of an enzymatic programmable peptide system inspired by endocytic processes to induce molecular assemblies formation spatiotemporally in living cancer cells, resulting in glioblastoma cell death mainly in necroptosis. Our results indicate the stability and glycosylation of molecules play an essential role in determining the final bioactivity. Detailed mechanistic studies by CLSM, Flow cytometry, western blot, and Bio‐EM suggest the site‐specific formation of assemblies, which could induce the LMP and activate the downstream cell death pathway. Moreover, we also demonstrate that our strategy can boost the activity of commercial chemotherapy drug by escaping lysosome sequestration. We expected this work would be expanded towards artificial intelligent biomaterials for cancer therapy and imaging precisely.
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