废止
化学
催化作用
环加成
表面改性
羟醛反应
组合化学
药物化学
有机化学
物理化学
作者
Sabera Sultana,Peter Yuosef M. Rubio,Hari Datta Khanal,Yong Rok Lee
标识
DOI:10.1021/acs.orglett.2c01538
摘要
The Sc(OTf)3/BF3·OEt2-catalyzed annulation of 3-formylchromones with functionalized alkenes for the direct construction of 2-hydroxybenzophenones is described. Sc(OTf)3/BF3·OEt2 acts as a synergistic catalyst, providing rapid synthetic access to diversely and highly functionalized 2-hydroxybenzophenones. This reaction has excellent regio- and chemoselectivities and is suitable for late-stage functionalization. The reaction proceeds via [3 + 3] and [4 + 2] cycloaddition processes, through carbonyl-ene, Diels-Alder, or aldol-type reactions. Furthermore, this protocol tolerates the various functional groups present in natural terpenes and steroids.
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