The newly non-uniform endometrial echogenicity on transvaginal ultrasound do not impact in vitro fertilization and embryo transfer success: A retrospective cohort study

To evaluate the effect of newly non-uniform endometrial echogenicity diagnosed by transvaginal ultrasound on the outcome of pregnancy in vitro fertilization-embryo transfer (IVF-ET) during controlled ovarian hyperstimulation (COH) by retrospective cohort analysis.A retrospective cohort study of a total of 604 patients with newly non-uniform endometrial echogenicity from January 2013 to June 2017, each woman was matched with three control subjects of similar age (±1 year), type of infertility (primary or secondary), the protocol used for COH, and the number of ET cycles in our unit. The patients in the study group and control group were matched according to the strict 1:3 matching principle. Baseline characteristics and pregnancy outcomes were compared.There were no statistically significant difference in baseline characteristics, live birth rate, biochemical pregnancy rate, clinical pregnancy rate, clinical pregnancy miscarriage rate and ectopic pregnancy rate between the two groups. But there were significant statistical differences in past history of uterine cavity surgery between the two groups (35.26% VS 21.19%), especially in history of endometrial polyp surgery (94.84% VS 90.10%).Our results demonstrate the newly diagnosed non-uniform endometrial echogenicity during controlled ovarian hyperstimulation does not affect the pregnancy outcome of in vitro fertilization-embryo transfer, and fresh embryo transfer can be continued.