神经退行性变
疾病
生物
细胞生物学
载脂蛋白E
基因
阿尔茨海默病
神经科学
脂质代谢
脂滴
遗传学
医学
病理
生物化学
作者
Matthew J. Moulton,Scott Barish,Isha Ralhan,Jinlan Chang,Lindsey D. Goodman,Jake G. Harland,Paul C. Marcogliese,Jan Johansson,Maria S. Ioannou,Hugo J. Bellen
标识
DOI:10.1073/pnas.2112095118
摘要
Significance Multiple studies have implicated dozens of risk loci that may be associated with Alzheimer’s disease (AD), but common mechanisms underlying how they may contribute to disease onset or progression remain elusive. This study identifies cell-specific roles for Drosophila orthologs of AD risk genes in lipid droplet formation that, when disrupted, lead to neurodegeneration. Our work reinforces a critical role for the sequestration of peroxidated lipids in glia, and places Apolipoprotein E ε4 (APOE4) with other AD risk factors in the transfer process of lipids from neurons to glia to form lipid droplets.
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