Multi-omics studies reveal genes critical for AKI and ferroptosis

Family-based linkage studies, more recently combined with exome sequencing, have identified coding regions that explain the development of cystic kidney diseases and nephrotic syndrome, as well as other rare kidney diseases; however, common adult-onset kidney diseases, including hypertensive and diabetic nephropathy, are multifactorial. These diseases show more complex inheritance patterns and less involvement of each causative region compared with the pure and rare genetic diseases, thus requiring a different approach to study them.