外显子组测序
肾病综合征
急性肾损伤
医学
肾病
生物信息学
肾脏疾病
外显子组
组学
基因
遗传连锁
遗传学
生物
计算生物学
糖尿病
内科学
突变
内分泌学
作者
Midori Sakashita,Masaomi Nangaku
标识
DOI:10.1016/j.kint.2021.10.032
摘要
Family-based linkage studies, more recently combined with exome sequencing, have identified coding regions that explain the development of cystic kidney diseases and nephrotic syndrome, as well as other rare kidney diseases; however, common adult-onset kidney diseases, including hypertensive and diabetic nephropathy, are multifactorial. These diseases show more complex inheritance patterns and less involvement of each causative region compared with the pure and rare genetic diseases, thus requiring a different approach to study them.
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