癌细胞
癌症
癌变
生物
缺氧(环境)
肿瘤微环境
细胞代谢
代谢途径
生物信息学
癌症研究
肿瘤细胞
新陈代谢
化学
生物化学
遗传学
氧气
有机化学
作者
Kateřina Hönigová,Jiří Navrátil,Barbora Peltanová,Hana Polanská,Martina Raudenská,Michal Masařík
标识
DOI:10.1016/j.bbcan.2022.188705
摘要
One of the characteristics of cancer cells important for tumorigenesis is their metabolic plasticity. Indeed, in various stress conditions, cancer cells can reshape their metabolic pathways to support the increased energy request due to continuous growth and rapid proliferation. Moreover, selective pressures in the tumor microenvironment, such as hypoxia, acidosis, and competition for resources, force cancer cells to adapt by complete reorganization of their metabolism. In this review, we highlight the characteristics of cancer metabolism and discuss its clinical significance, since overcoming metabolic plasticity of cancer cells is a key objective of modern cancer therapeutics and a better understanding of metabolic reprogramming may lead to the identification of possible targets for cancer therapy.
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