This study investigates the relationships among socio-emotional skills, personality traits, and perceived parenting practices in Colombian adolescents, examining the mediating role of perceived parenting practices using partial least squares structural equation modeling. The study sample consisted of 502 adolescents aged 14-17 from various socioeconomic backgrounds in Colombia. Participants completed validated self-report measures: BarOn EQ-i:YV for socio-emotional skills, CEPER III for personality traits, and the Andrade and Betancourt Scale for Perceived Parenting Practices. Results indicated that maladaptive personality traits negatively impacted socio-emotional skills and perceived parenting practices. Perceived positive parenting practices positively influenced socio-emotional skills and mediated the relationship between personality traits and socio-emotional skills. These findings highlight the essential role of parenting practices as a mechanism of mediating between personality traits and adolescent socio-emotional skills. The study underscores the importance of personality assessment and targeted parenting interventions to foster adolescents' emotional and social skills.