生物
免疫疗法
癌症免疫疗法
黑色素瘤
抗原
撞击坑
斑马鱼
T细胞
癌症研究
多路复用
免疫检查点
细胞生物学
癌症
肿瘤微环境
细胞
FOXP3型
抗原呈递
免疫学
转录组
封锁
离体
体内
嵌合抗原受体
抗原提呈细胞
免疫系统
作者
Aya Ludin,Georgia L. Stirtz,Asaf Tal,Ajit J. Nirmal,Kathleen L. Pfaff,Michael P. Manos,N. Besson,Nebiyat Eskndir,Billie Porter,Stephanie M. Jones,Hannah Mae Faulkner,Qiyu Gong,Sophia Liu,Irving Barrera,Lijian Wu,Cecília Pessoa Rodrigues,Aditi Sahu,Elizabeth R. Jerison,Joao V. Alessi,Biagio Ricciuti
出处
期刊：Cell
[Cell Press]
日期：2025-10-17
卷期号：188 (24): 6720-6736.e26
被引量：8
标识
DOI：10.1016/j.cell.2025.09.021
摘要
T cell accumulation and tumor killing. In humans, elevation in CRATER density in biopsies following immune checkpoint blockade (ICB) therapy correlated with a clinical response to therapy. CRATERs are structures that show active tumor killing and may be useful as a diagnostic indicator for immunotherapy success.
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