HDAC6型
海马体
海马结构
神经科学
生物
细胞凋亡
神经递质
阿尔茨海默病
疾病
组蛋白脱乙酰基酶
内科学
内分泌学
医学
细胞生物学
药理学
中枢神经系统
组蛋白
基因
生物化学
作者
Ruihua Liu,Linli Guo,Yanan Zhao,Dan Wu,Jiasi Yu,Ping Liu
出处
期刊:Brain Research
[Elsevier BV]
日期:2024-03-03
卷期号:1832: 148847-148847
被引量:2
标识
DOI:10.1016/j.brainres.2024.148847
摘要
Histone deacetylase 6 (HDAC6) is a key therapeutic target in neurodegenerative diseases such as Alzheimer's disease (AD), which has been demonstrated to play an essential role in memory function and microtubule-associated tau physiology. In this study, W5 was used to treat AD model rats induced by Aβ/Cu2+ to study the improving effect of W5 on learning and memory impairment in AD rats and its related mechanism, to provide the basis for the subsequent development of W5 as an anti-AD drug. Results showed that W5 could decrease the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats to inhibit the formation of senile plaques and neurofibrillary tangles, down-regulate the expression of Bax mRNA and Caspase-3 mRNA, and up-regulate the expression of Bcl-2 mRNA to reduce the apoptosis of neuron cells, reverse the expression of TNF-α, IL-1β and IL-6 mRNA to regulate neuroinflammatory response in AD rat brain. W5 also could regulate the oxidative stress state of AD rats, and balance the neurotransmitter disorder in AD rats' brain tissue. Overall, W5 could recover the morphology of hippocampal neurons and improve the learning and memory dysfunction in AD rats by regulating multiple targets in AD rats, providing a promising therapeutic avenue for the treatment of AD.
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