Dynamic prefrontal inhibition code mediates reward devaluation

Repeated reward intake decreases its subjective pleasantness, which is a common phenomenon called reward devaluation. In this issue of Neuron, Yuan et al. 1 Yuan Z. Qi Z. Wang R. Cui Y. An S. Wu G. Feng Q. Lin R. Dai R. Li A. et al. A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code. Neuron. 2023; 111: 3837-3853https://doi.org/10.1016/j.neuron.2023.08.022 Abstract Full Text Full Text PDF Scopus (1) Google Scholar unravel that blunted inhibitory response of anterior cingulate cortex (ACC) encodes this process, whose hypersensitization leads to anhedonia. Repeated reward intake decreases its subjective pleasantness, which is a common phenomenon called reward devaluation. In this issue of Neuron, Yuan et al. 1 Yuan Z. Qi Z. Wang R. Cui Y. An S. Wu G. Feng Q. Lin R. Dai R. Li A. et al. A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code. Neuron. 2023; 111: 3837-3853https://doi.org/10.1016/j.neuron.2023.08.022 Abstract Full Text Full Text PDF Scopus (1) Google Scholar unravel that blunted inhibitory response of anterior cingulate cortex (ACC) encodes this process, whose hypersensitization leads to anhedonia. A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition codeYuan et al.NeuronSeptember 20, 2023In BriefYuan et al. show that the neural pathway from the anterior cingulate cortex (ACC) to the basolateral amygdala (BLA) employs a dynamic inhibition code to control reward devaluation and depression. Silencing ACC desensitizes reward devaluation and enhances reward intake, suggesting a viable therapeutic approach for treating depression. Full-Text PDF