骨愈合
粘蛋白
自愈水凝胶
体内
再生(生物学)
再生医学
细胞生物学
背景(考古学)
血运重建
血管生成
化学
伤口愈合
癌症研究
免疫学
医学
解剖
干细胞
生物
生物化学
内科学
古生物学
有机化学
生物技术
心肌梗塞
作者
Song Chen,Huan Wang,Dachuan Liu,Jianzhong Bai,Håvard Jostein Haugen,Bin Li,Hongji Yan
标识
DOI:10.1016/j.bioactmat.2023.01.022
摘要
The design principle of osteogenic bone grafts has shifted from immunological inertness to limiting foreign body response to combined osteoimmunomodulatory activity to promote high-quality endogenous bone regeneration. Recently developed immunomodulatory mucin hydrogels have been shown to elicit very low complement activation and suppress macrophage release and activation after implantation in vivo. However, their immunoregulatory activity has not yet been studied in the context of tissue repair. Herein, we synthesized mucin-monetite composite materials and investigated their early osteoimmunomodulation using a critical-size rat bone defect model. We demonstrated that the composites can polarize macrophages towards the M2 phenotype at weeks 1 and 2. The early osteoimmunomodulation enhanced early osteogenesis and angiogenesis and ultimately promoted fracture healing and engraftment (revascularization of the host vasculature) at weeks 6 and 12. Overall, we demonstrated the applicability of mucin-based immunomodulatory biomaterials to enhance tissue repair in tissue engineering and regenerative medicine.
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