再生(生物学)
组织工程
脚手架
细胞外基质
自愈水凝胶
琼脂糖
再生医学
化学
表面改性
纳米技术
生物医学工程
细胞生物学
材料科学
生物化学
生物
工程类
细胞
物理化学
有机化学
作者
Zhaokun Wang,Z. Xu,Xuan Yang,Man Li,Ryan Chak Sang Yip,Hao Chen
出处
期刊:Biomaterials advances
日期:2023-11-01
卷期号:154: 213580-213580
被引量:7
标识
DOI:10.1016/j.bioadv.2023.213580
摘要
Marine polysaccharides (MPs) are exceptional bioactive materials that possess unique biochemical mechanisms and pharmacological stability, making them ideal for various tissue engineering applications. Certain MPs, including agarose, alginate, carrageenan, chitosan, and glucan have been successfully employed as biological scaffolds in animal studies. As carriers of signaling molecules, scaffolds can enhance the adhesion, growth, and differentiation of somatic cells, thereby significantly improving the tissue regeneration process. However, the biological benefits of pure MPs composite scaffold are limited. Therefore, physical, chemical, enzyme modification and other methods are employed to expand its efficacy. Chemically, the structural properties of MPs scaffolds can be altered through modifications to functional groups or molecular weight reduction, thereby enhancing their biological activities. Physically, MPs hydrogels and sponges emulate the natural extracellular matrix, creating a more conducive environment for tissue repair. The porosity and high permeability of MPs membranes and nanomaterials expedite wound healing. This review explores the distinctive properties and applications of select MPs in tissue regeneration, highlighting their structural versatility and biological applicability. Additionally, we provide a brief overview of common modification strategies employed for MP scaffolds. In conclusion, MPs have significant potential and are expected to be a novel regenerative material for tissue engineering.
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