对映选择合成
化学
卤素
催化作用
组合化学
镍
烷基
卤化物
转移加氢
光催化
电子转移
Atom(片上系统)
光催化
光化学
有机化学
钌
嵌入式系统
计算机科学
作者
Sheng Lü,Zihao Hu,Dong Wang,Tao Xu
标识
DOI:10.1002/ange.202406064
摘要
With halogen‐atom transfer as an effective tool, a novel catalytic enantioselective protocol to generate chiral trifluoromethylated alkynes has been established by a cooperative photoredox and nickel catalysis system, providing a straightforward and modular route to access this type of product in good yields and enantioselectivities. The halogen‐atom transfer process is essential for the reaction and this novel strategy offers another promising way to utilize alkyl halides with highly negative reduction potentials. It firstly expands nickel‐catalyzed asymmetric reductive cross‐couplings of organohalides from the traditional single‐electron transfer to halogen‐atom transfer.
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