医学
主动脉炎
血管炎
巨细胞动脉炎
动脉炎
疾病
放射科
炎症
正电子发射断层摄影术
病理
内科学
主动脉
作者
François Jamar,Lars Christian Gormsen,Halil Yıldız,Riemer H. J. A. Slart,Kornelis S. van der GEEST,Olivier Gheysens
出处
期刊:Quarterly Journal of Nuclear Medicine and Molecular Imaging
[Edizioni Minerva Medica]
日期:2022-09-01
卷期号:66 (3)
被引量:4
标识
DOI:10.23736/s1824-4785.22.03465-3
摘要
Large vessel vasculitides (LVV) are defined as chronic inflammatory disorders that affect the arteries with two major variants being distinguished: giant cell arteritis (GCA) and Takayasu’s arteritis (TAK). These often present with nonspecific constitutional symptoms which makes an accurate diagnosis often challenging. Nevertheless, timely diagnosis is of utmost importance to initiate treatment and to avoid potential life-threatening complications. [18F]FDG-PET/CT is nowadays widely accepted as useful tool to aid in the diagnosis of large vessel vasculitis. However, its role to monitor disease activity and to predict disease relapse during follow-up is less obvious since vascular [18F]FDG uptake can be detected in the absence of clinical or biochemical signs of disease activity. In addition to the two major variants, [18F]FDG-PET/CT has shown promise in (peri-)aortitis and related disorders. This article aims to provide an update on the current knowledge and limitations of [18F]FDG-PET/CT for the diagnosis and assessment of treatment response in LVV. Furthermore, other radiopharmaceuticals targeting key components of the vascular immune system are being discussed which could provide an interesting alternative to image vascular inflammation in LVV.
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