钆
磁共振成像
生物相容性
磁共振血管造影
肾源性系统性纤维化
核磁共振
材料科学
磁共振造影剂
对比度(视觉)
顺磁性
核医学
生物医学工程
医学
放射科
物理
人工智能
冶金
量子力学
计算机科学
作者
Rodrigo Ken Kawassaki,Mariana Romano,Mayara Klimuk Uchiyama,Roberta M. Cardoso,Maurı́cio S. Baptista,Sandra Helena Poliselli Farsky,Khallil Taverna Chaim,Robson Raphael Guimarães,Koiti Araki
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-06-10
卷期号:23 (12): 5497-5505
被引量:4
标识
DOI:10.1021/acs.nanolett.3c00665
摘要
Nanostructured contrast agents are promising alternatives to Gd3+-based chelates in magnetic resonance (MR) imaging techniques. A novel ultrasmall paramagnetic nanoparticle (UPN) was strategically designed to maximize the number of exposed paramagnetic sites and r1 while minimizing r2, by decorating 3 nm titanium dioxide nanoparticles with suitable amounts of iron oxide. Its relaxometric parameters are comparable to those of gadoteric acid (GA) in agar phantoms, and the r2/r1 ratio of 1.38 at 3 T is close to the ideal unitary value. The strong and prolonged contrast enhancement of UPN before renal excretion was confirmed by T1-weighted MR images of Wistar rats after intravenous bolus injection. Those results associated with good biocompatibility indicate its high potential as an alternative blood-pool contrast agent to the GA gold standard for MR angiography, especially for patients with severe renal impairment.
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