Basophil-VAMP7 is a vital regulator of skin barrier integrity and chronic itch

VAMP7 is essential for basophil-driven chronic itch and AIF in AD by maintaining basophil activity, regulating skin barrier damage in AIF via the OSM pathway, and modulating chronic itch through the CCL24/CCR3 axis. Targeting basophil-VAMP7 offers a potential strategy to restore skin barrier function in AIF and alleviate chronic itch in AD.