细胞毒性
合理设计
钌
组合化学
纳米技术
化学
材料科学
体外
生物化学
催化作用
作者
Zhen-Feng Chen,Chris Orvig,Hong Liang
标识
DOI:10.2174/1568026617666171004155437
摘要
There has been a growing interest in the rational design of multi-targeted drugs with the aim of enhancing overall efficacy and/or improving safety. The development of multi-targeted drugs might yield new avenues in the treatment of cancers that involve multiple pathogenic factors. In this review, we focus on the multi-targeted metal-based anticancer agents, which include platinum, ruthenium, rhodium, gold, silver, copper, cobalt, zinc, and nickel complexes. Future directions for the development of multi-targeted metal-based anticancer agents are also proposed. Keywords: Multi-target, metal complexes, cytotoxicity, anticancer agents, nickel complexes, pathogenic factors.
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