医学
氧化应激
NADPH氧化酶
活性氧
认知障碍
疾病
神经科学
平衡
冲程(发动机)
认知
内科学
细胞生物学
精神科
生物
机械工程
工程类
作者
Costantino Iadecola,Laibaik Park,Carmen Capone
出处
期刊:Stroke
[Ovid Technologies (Wolters Kluwer)]
日期:2009-03-01
卷期号:40 (3_suppl_1)
被引量:193
标识
DOI:10.1161/strokeaha.108.533638
摘要
Aging, Alzheimer disease, and hypertension, major determinants of cognitive dysfunction, are associated with profound alterations in the structure and function of cerebral blood vessels. These vascular alterations may impair the delivery of energy substrates and nutrients to the active brain, and impede the clearance of potentially toxic metabolic byproducts. Reactive oxygen species derived form the enzyme NADPH oxidase are key pathogenic effectors of the cerebrovascular dysregulation. The resulting alterations in the homeostasis of the cerebral microenvironment may lead to cellular dysfunction and death and to cognitive impairment. The prominent role that cerebrovascular oxidative stress plays in conditions associated with cognitive impairment suggests new therapeutic opportunities to counteract and, possibly, reverse the devastating effects of cerebrovascular dysfunction on the brain.
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