NBQX公司
NMDA受体
谷氨酸受体
化学
药理学
喹喔啉
硝基
甘氨酸
缺血
敌手
AMPA受体
受体
医学
生物化学
内科学
氨基酸
有机化学
烷基
作者
Malcolm J. Sheardown,Elsebet Ø. Nielsen,Anker Jón Hansen,Poul Jacobsen,Tage Honoré
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1990-02-02
卷期号:247 (4942): 571-574
被引量:1093
标识
DOI:10.1126/science.2154034
摘要
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non- N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.
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