药效团
化学
氨基脲
药物发现
血小板生成素
高通量筛选
组合化学
小分子
效力
水杨醛
结构-活动关系
立体化学
生物活性
计算生物学
化学合成
生物化学
体外
席夫碱
生物
造血
遗传学
干细胞
作者
Kevin J. Duffy,Anthony N. Shaw,Evelyne Delorme,Susan B. Dillon,Connie L. Erickson‐Miller,Leslie Giampa,Yaoxin Huang,Richard M. Keenan,Peter Lamb,Nannan Liu,Stephen G. Miller,Alan T. Price,Jon Rosen,Heather Smith,Kenneth J. Wiggall,Lihua Zhang,Juan I. Luengo
摘要
High-throughput screening has resulted in the discovery of thiosemicarbazone thrombopoietin mimics. A shared pharmacophore hypothesis between this series and a previously identified class, the pyrazol-4-ylidenehydrazines, led to the rapid optimization of both potency and efficacy of the thiosemicarbazones. The application of high-throughput chemistry and purification techniques allowed for the rapid elucidation of structure-activity relationships.
科研通智能强力驱动
Strongly Powered by AbleSci AI