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Psyllium and fat in diets differentially affect the activities and expressions of colonic sphingomyelinases and caspase in mice

鞘磷脂 木虱 鞘磷脂磷酸二酯酶 神经酰胺 内科学 内分泌学 化学 碱性磷酸酶 鞘脂 酸性鞘磷脂酶 细胞凋亡 生物化学 生物 医学 胆固醇 食品科学 膳食纤维
作者
Yajun Cheng,Lena Ohlsson,Rui‐Dong Duan
出处
期刊:British Journal of Nutrition [Cambridge University Press]
卷期号:91 (5): 715-723 被引量:38
标识
DOI:10.1079/bjn20041107
摘要

Dietary fibre and fat affect colonic tumourigenesis and inflammation. Sphingomyelin metabolism may have implications for the pathogenesis of colonic tumours and ulcerative colitis. The present study examined the effects of psyllium and fat on the enzymes responsible for sphingomyelin metabolism and apoptosis in the colon. Mice were fed control, psyllium-containing (100 g/kg), high-fat (313 g/kg, 53 % energy as fat) or high-fat plus psyllium diets for 4 weeks. The activities of acid, neutral and alkaline sphingomyelinase (SMase), neutral ceramidase, and caspase 3, 8 and 9 in colonic mucosa were determined. The expressions of alkaline SMase and caspase 3 were examined. The psyllium-containing diet was found to increase significantly the activities of alkaline SMase and caspase 3 and decreased those of acid SMase and neutral ceramidase. The high-fat diet had opposite effects on these enzymes and attenuated the effects of psyllium. Western blotting showed that psyllium increased and high-fat decreased the levels of alkaline SMase and caspase 3 in colonic mucosa. The change in caspase 3 activity was positively correlated with that of alkaline SMase and negatively with acid SMase. No similar changes of acid and alkaline phosphatase activities in the colon or acid and neutral SMase activity in the liver were identified. In conclusion, colonic sphingomyelin metabolism and apoptosis were affected by psyllium and fat in an opposite manner. The results may have implications for colorectal tumourigenesis and inflammation.
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