滋养层
蜕膜化
子宫内膜
怀孕
血管生成
粒细胞巨噬细胞集落刺激因子
集落刺激因子
生物
粒细胞集落刺激因子
粒细胞
免疫学
医学
内分泌学
胎盘
胎儿
内科学
细胞因子
造血
细胞生物学
干细胞
化疗
遗传学
作者
Jinli Ding,Jing Wang,Xiaopeng Cai,Tailang Yin,Yan Zhang,Chaogang Yang,Jing Yang
标识
DOI:10.1016/j.biopha.2022.112903
摘要
Granulocyte colony-stimulating factor (G-CSF) is one of the cytokines which plays important roles in embryo implantation and normal pregnancy. At the maternal-fetal interface, G-CSF can be synthesized by multiple cells, and participates in regulation of trophoblast development, endometrial decidualization, placental metabolism and angiogenesis. Moreover, as an important medium of intercellular communication, G-CSF has also been shown to exert key roles in crosstalk between cellular components at the maternal-fetal interface. Recently, our study demonstrated that G-CSF derived from M2 macrophage could promote trophoblasts invasion and migration through activating PI3K/AKT/Erk1/2 pathway, thereby involving in normal pregnancy program. Herein, we will summarize the role and regulation of G-CSF in normal pregnancy and reproductive-related disease, and the clinical applications of G-CSF in patients undergoing in vitro fertilization with thin endometrium, repeated implantation failure, and women suffered with recurrent spontaneous abortion.
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