Nickel-Catalyzed Reductive Cascade Arylalkylation of Alkenes with Alkylpyridinium Salts

Herein, we describe a nickel-catalyzed reductive deaminative arylalkylation of tethered alkenes with pyridinium salts as C(sp³) electrophiles. This two-component dicarbofunctionalization reaction enables the efficient synthesis of various benzene-fused cyclic compounds bearing all-carbon quaternary centers. The approach presented in this paper proceeds under mild conditions, tolerating a wide variety of functional groups and heterocycles. It has been used to functionalize complicated molecules at a late stage.