表面改性
催化作用
化学
选择性
有机化学
光催化
组合化学
光催化
物理化学
作者
Jian‐Heng Ye,Peter Bellotti,Corinna Heusel,Frank Glorius
标识
DOI:10.1002/anie.202115456
摘要
Selective C-F bond functionalization of perfluoalkyl units has huge potential towards accessing functionalized organofluorinated compounds, but remains challenging due to the high C-F bond strength and inherent selectivity challenges. We report a new catalytic approach to the selective functionalization of strong C-F bonds in polyfluorinated aliphatic esters and amides. This simple reaction proceeds in mild and operational fashion with divergent conversions, including hydrodefluorination, defluoroalkylation, and defluoroalkenylation, affording a diverse array of important partially fluorinated motifs. Straightforward downstream chemistry towards fluorinated alcohols, amines and drug derivatives highlights the potential of the protocol.
科研通智能强力驱动
Strongly Powered by AbleSci AI