Update on Exosomes in Aesthetics

BACKGROUND In dermatology, exosomes have been leveraged given their roles in wound healing, cell migration, extracellular matrix reconstruction, and angiogenesis. OBJECTIVE The purpose of this article is to review the literature investigating the use of exosomes in skin rejuvenation and hair regeneration. MATERIALS AND METHODS The PubMed database was searched for studies published through October 2021. RESULTS Early preclinical studies in aesthetics have demonstrated promising effects of exosomes on skin rejuvenation and hair growth in in vitro and murine models. Despite this, only 1 clinical study has been published to date, and there are no FDA-approved products on the market. CONCLUSION Variation in purification techniques and practical issues surrounding isolation, storage, scalability, and reproducibility of an exosome product represent ongoing hindrances to the movement of exosomes into the clinical sphere.