烯烃
催化作用
化学
组合化学
选择性
镍
基质(水族馆)
还原消去
有机化学
海洋学
地质学
作者
Jia-Wang Wang,Deguang Liu,Zhe Chang,Zhen Li,Yao Fu,Xi Lü
标识
DOI:10.1002/ange.202205537
摘要
Regiodivergent alkene functionalization that produces either regioisomer starting from the same raw materials is desirable. Herein, we report a nickel-catalyzed switchable site-selective alkene hydroalkylation. The selection of reaction temperatures leads to protocols that provide regiodivergent hydroalkylated products starting from a single alkene substrate. This protocol allows the convenient synthesis of α- and β-branched protected amines, both of which are important to the fields of pharmaceutical chemistry and biochemistry. In addition, enantioenriched β-branched alkylamines can be accessed in a catalytic asymmetric variant. Preliminary mechanistic studies indicate that the formation of a more stable nickelacycle provides the driving force of migration. The thermodynamic and kinetic properties of different reduction elimination intermediates are responsible for the switchable site-selectivity.
科研通智能强力驱动
Strongly Powered by AbleSci AI