The aim of this case report was to prosthodontically rehabilitate and boost the psychological development of the patient. Ectodermal dysplasia is a hereditary condition presented with abnormal development of tissues of ectodermal origin such as hair, skin, nails, and teeth. This condition generally presented with following signs and symptoms; dental abnormalities, onychodysplasia, hypohidrosis, and hypotrichosis. Ectodermal dysplasia usually has an X-linked recessive trait, with most common being of hypohidrotic ectodermal dysplasia also known as Christ-Siemens-Touraine syndrome. This case report describes the prosthetic rehabilitation with conventional dentures in maxillary arch and tooth supported overdenture in mandibular arch of a young boy with hypohidrodic ectodermal dysplasia. Prosthetic treatment is very helpful to these patients from functional, psychological, and psychosocial points of view. Need for continued dental treatment is necessary.