微泡
外体
细胞生物学
再生(生物学)
组织工程
生物材料
免疫系统
化学
生物
生物医学工程
医学
免疫学
小RNA
生物化学
基因
作者
Wentao Wang,Xiaoyao Liang,Kai Zheng,Gaoran Ge,Chunxiang Xu,Yaozeng Xu,Jiaxiang Bai,Guoqing Pan,Dechun Geng
标识
DOI:10.1016/j.mtbio.2022.100355
摘要
Bone injury repair has always been a tricky problem in clinic, the recent emergence of bone tissue engineering provides a new direction for the repair of bone injury. However, some bone tissue processes fail to achieve satisfactory results mainly due to insufficient vascularization or cellular immune rejection. Exosomes with the ability of vesicle-mediated intercellular signal transmission have gained worldwide attention and can achieve cell-free therapy. Exosomes are small vesicles that are secreted by cells, which contain genetic material, lipids, proteins and other substances. It has been found to play the function of material exchange between cells. It is widely used in bone tissue engineering to achieve cell-free therapy because it not only does not produce some immune rejection like cells, but also can play a cell-like function. Exosomes from different sources can bind to scaffolds in various ways and affect osteoblast, angioblast, and macrophage polarization in vivo to promote bone regeneration. This article reviews the recent research progress of exosome-loaded tissue engineering, focusing on the mechanism of exosomes from different sources and the application of exosome-loaded scaffolds in promoting bone regeneration. Finally, the existing deficiencies and challenges, future development directions and prospects are summarized.
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