Tf2O-Promoted Chemoselective C3 Functionalization of Anthranils with Phenols and Thiophenols

Different chemoselectivities of phenols and thiophenols were observed in a Tf2O-promoted C3 functionalization of simple anthranils. The reaction of phenols and anthranils gives 3-aryl anthranils via a C–C bond formation, whereas thiophenols afford 3-thio anthranils through a C–S bond formation. Both reactions have a broad substrate scope and tolerate a wide range of functional groups, affording the corresponding products with specific chemoselectivity.