硝基苯
化学
戒指(化学)
肟
试剂
组合化学
对映选择合成
二乙基锌
有机化学
催化作用
作者
Na Li,Biqiong Hong,Jinbo Zhao,Zhenhua Gu
标识
DOI:10.1002/anie.202215530
摘要
Nitrenes and nitrenoids are highly reactive species and the proposed key intermediates in nitrogen-containing heterocyclic compound synthesis. In this work, we developed a practical method for the synthesis of phenanthridines by the reaction of oximes and Grignard reagents (with or without diethylzinc) via ring-expansion of magnesium coordinated nitrenoid complex as the key step. The method has been used to synthesize optically active planar chiral ferrocenyl phenanthridines.
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