医学
哮喘
维生素D与神经学
优势比
过敏
维生素D缺乏
儿科
队列
前瞻性队列研究
内科学
免疫学
作者
Júlia Sangüesa,Jordi Sunyer,Raquel García-Esteban,Alicia Abellan,Ana Esplugues,Judith Garcia‐Aymerich,Mònica Guxens,Amaia Irizar,Jordi Júlvez,Leire Luque-García,Ana Cristina Rodríguez-Dehli,Adonina Tardón,Maties Torrent,Jesús Vioque,Martine Vrijheid,Maribel Casas
标识
DOI:10.1038/s41390-022-02256-9
摘要
BackgroundEarly-life vitamin D deficiency may impair immune system development contributing to allergy and asthma onset. Findings from prospective studies are inconsistent.ObjectiveTo examine whether maternal and child vitamin D levels are associated with allergic and asthma-related symptoms throughout childhood in a Spanish birth cohort.Methods25-Hydroxyvitamin D3 (25(OH)D3) levels were measured in the serum of pregnant women (N = 2525) and children (N = 803). Information on allergic and asthma-related symptoms was obtained from repeated questionnaires from 1 to 9 years.ResultsA total of 19% of mothers and 24% of children had deficient 25(OH)D3 levels (<20 ng/ml). Higher child 25(OH)D3 levels at 4 years were associated with lower odds of atopic eczema from 4 to 9 years (adjusted odds ratio = 0.90; 95% CI = 0.84–0.97 per 5 ng/ml). Higher maternal and child 25(OH)D3 levels were associated with a lower prevalence of late-onset wheezing at the limit of statistical significance (adjusted relative risk ratio (RRRadj) = 0.86; 95% CI = 0.74–1.00 and RRRadj = 0.76; 95% CI = 0.58–1.02 per 5 ng/ml, respectively). All the remaining associations were null.ConclusionChild 25(OH)D3 levels at pre-school age are associated with a reduced odds of atopic eczema in later childhood and both maternal and child levels may reduce the prevalence of late-onset wheezing.Impact In this Spanish birth cohort, with a total of 19% of mothers and 24% of children with deficient levels of vitamin D, higher child vitamin D at 4 years of age was associated with reduced odds of atopic eczema up to 9 years. There was also some evidence that higher maternal and child vitamin D levels reduced the prevalence of late-onset wheezing. Although these findings need replication, they may imply optimal vitamin D levels at pre-school age to prevent atopic eczema.
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