化学
立体化学
单萜
吲哚试验
吲哚生物碱
戒指(化学)
辛烷值
部分
咪唑
生物碱
夹竹桃科
量子化学
双环分子
分子
有机化学
植物
生物
作者
Guanqun Zhan,Fuxin Zhang,Kailing Yang,Tao Yang,Ruixi Zhou,Wenwen Chen,Jingwei Zhang,Xinxin Zhang,Zengjun Guo
摘要
Alscholarines A and B (1 and 2), two unprecedented rearranged monoterpene indole alkaloids, were isolated from Alstonia scholaris. Alscholarine A (1) features an imidazole ring fused with a rearranged vallesamine-type alkaloid possessing an unparalleled 6/5/6/6 tetracyclic skeleton through an unprecedented C7-C-19 connectivity. Alscholarine B (2), incorporating an unusual 7-oxa-1-azabicyclo[3.2.1]octane moiety, represents a unique rearranged vallesamine-type alkaloid with a 6/5/6/6/5 ring system via an unprecedented C-6-C-20 connectivity. Their structures were established by spectroscopic analysis, X-ray crystallography, and quantum-chemical calculations. Their plausible biosynthetic pathways were proposed. The vasorelaxant and anti-inflammatory activities of them were also evaluated. Compounds 1-3 showed moderate vasorelaxant activities.
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