成纤维细胞
炎症
生物
免疫系统
免疫学
银屑病
伤口愈合
成纤维细胞生长因子
人体皮肤
细胞生物学
受体
细胞培养
遗传学
作者
Zhiguo Li,Tianyu Cao,Qingyang Li,Jingliang Zhang,Juan Du,Jiaoling Chen,Yaxing Bai,Junfeng Hao,Zhenlai Zhu,Hongjiang Qiao,Meng Fang,Erle Dang,Gang Wang,Shuai Shao
标识
DOI:10.1016/j.clim.2023.109742
摘要
Fibroblasts are critical pro-inflammatory regulators in chronic inflammatory and fibrotic skin diseases. However, fibroblast heterogeneity and the absence of a unified cross-disease taxonomy have hindered our understanding of the shared/distinct pathways in non-communicable skin inflammation. By integrating 10× single-cell data from 75 skin samples, we constructed a single-cell atlas across inflammatory and fibrotic skin diseases and identified 9 distinct subsets of skin fibroblasts. We found a shared subset of CCL19+ fibroblasts across these diseases, potentially attracting and educating immune cells. Moreover, COL6A5+ fibroblasts were a distinct subset implicated in the initiation and relapse of psoriasis, which tended to differentiate into CXCL1+ fibroblasts, inducing neutrophil chemotaxis and infiltration; while CXCL1+ fibroblasts exhibited a more heterogeneous response to certain inflammatory conditions. Differentiation trajectory and regulatory factors of these fibroblast subsets were also revealed. Therefore, our study presents a comprehensive atlas of skin fibroblasts and highlights pathogenic fibroblast subsets in skin disorders.
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