Asprosin mediates diabetes-associated depression via provoking the cascade of pyroptosis-neuroinflammation-kynurenine pathway disorder in the hippocampus

levels in the hippocampus of diabetic rats. Conversely, Asprosin overexpression exacerbated hippocampal neuroinflammation, pyroptosis, and KP disorder. These findings suggest that hippocampal Asprosin may contribute to diabetes-associated depression, possibly by provoking the cascade of pyroptosis-neuroinflammation-KP disorder.