奶油
癌症研究
前列腺
前列腺癌
细胞生长
基因
肺癌
癌症
信号转导
生物
内科学
医学
内分泌学
化学
细胞生物学
遗传学
转录因子
作者
Michael A. James,Yan Lü,Yan Liu,Haris G. Vikis,Ming You
标识
DOI:10.1158/0008-5472.c.6499340
摘要
<div>Abstract<p>We have identified RGS17 as a commonly induced gene in lung and prostate tumors. Through microarray and gene expression analysis, we show that expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Through knockdown and overexpression of RGS17 in tumor cells, we show that RGS17 confers a proliferative phenotype and is required for the maintenance of the proliferative potential of tumor cells. We show through exon microarray, transcript analysis, and functional assays that RGS17 promotes cyclic AMP (cAMP)-responsive element binding protein (CREB)-responsive gene expression, increases cAMP levels, and enhances forskolin-mediated cAMP production. Furthermore, inhibition of cAMP-dependent kinase prevents tumor cell proliferation, and proliferation is partially rescued by RGS17 overexpression. In the present study, we show a role for RGS17 in the maintenance of tumor cell proliferation through induction of cAMP signaling and CREB phosphorylation. The prevalence of the induction of RGS17 in tumor tissues of various types further implicates its importance in the maintenance of tumor growth. [Cancer Res 2009;69(5):2108–16]</p></div>
科研通智能强力驱动
Strongly Powered by AbleSci AI